Title: Can Computational Modeling Inform Intervention Strategies to Mitigate the Impact of Developmental Abnormalities?

Abstract: Branched, tree-like structures, such as the lung airways and mammary ducts, are vital for fluid transport in mammals. They facilitate the secretion and distribution of essential substances, as well as the removal of waste, thereby supporting diverse physiological functions. The formation of these tree-like structures typically begins during embryonic development. Defects in branching morphogenesis — the process that governs the formation of these structures — can lead to rare syndromes or common conditions, such as impaired lung function, chronic obstructive pulmonary disease (COPD), and breast cancer. How the formation of these tree-like structures affects the susceptibility to chronic diseases is not well understood. Understanding how organ development impacts long-term health can aid in early diagnosis, prevention, and intervention strategies to mitigate the effects of developmental abnormalities.

In this talk, I will present a novel integration of laboratory experimentation, image analysis, optimal transport theory and multifractal theory to elucidate branching morphogenesis in the lungs and mammary gland. I will also present a novel computational approach that can link lung airway formation to susceptibility to chronic diseases such as COPD. I will demonstrate how we plan to use computational modeling to inform intervention strategies aimed at mitigating the impact of developmental abnormalities on susceptibility to chronic diseases such as COPD.